University of Iowa Technology Institute has a broad and productive research mission that has yielded numerous successful technologies in the areas of flight testing and human performance, human modeling and simulation, driving and transportation, advanced manufacturing technology and robotics, biomedical and biochemical science and engineering, machine learning, smart sensors, remote sensing, renewable energy, and modeling of environmental change.

Some of the core technologies that differentiate ITI include the Iowa Driving Simulator, the National Advanced Driving Simulator, the virtual human Santos, and the Cognitive Avionics Tool Set. 

ITI technology has contributed to the US Army, Air Force, Navy, Marine Corps, and companies such as Ford, GM, Chrysler, Collins Aerospace, John Deere, Caterpillar, NASA, and many others.